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Mar 18, 2024
10:13 PM
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Cenforce 100 mg is a medication primarily used to treat erectile dysfunction (ED), a condition characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. It contains sildenafil citrate, a potent inhibitor of the enzyme phosphodiesterase type 5 (PDE5). Understanding how Cenforce 100 works requires insight into the physiological mechanisms underlying ED and the pharmacological actions of sildenafil citrate.
Erectile dysfunction often arises from insufficient blood flow to the penis, which can be caused by various factors such as age, diabetes, hypertension, or psychological issues. When a man is sexually aroused, the release of nitric oxide (NO) in the corpus cavernosum of the penis leads to the activation of an enzyme called guanylate cyclase. This enzyme increases the levels of cyclic guanosine monophosphate (cGMP), which in turn relaxes the smooth muscles in the blood vessels of the penis, allowing them to dilate and increase blood flow. Enhanced blood flow into the penis results in an erection.
However, the action of PDE5 can degrade cGMP, leading to a reduction in penile blood flow and subsequent erectile dysfunction. Sildenafil citrate in Cenforce 100 works by inhibiting PDE5, thereby preventing the degradation of cGMP and promoting its accumulation in the corpus cavernosum. This leads to prolonged relaxation of smooth muscles and increased blood flow to the penis, facilitating the achievement and maintenance of an erection when sexually stimulated.
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