Yes, Super Avana, which combines Avanafil and Dapoxetine, can cause headaches as a side effect. Both components of the medication have been associated with headaches:

Avanafil: As a PDE5 inhibitor, Avanafil can cause headaches due to its effect on blood vessels and increased blood flow to the head.

Dapoxetine: This selective serotonin reuptake inhibitor (SSRI) used for premature ejaculation can also cause headaches as a side effect.

If you experience persistent or severe headaches while using Super Avana, it's important to consult with your healthcare provider. They can help determine if the headaches are related to the medication and suggest potential adjustments or alternatives if necessary.